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Glutamate dehydrogenase structure
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Families of Dehydrogenases

About dehydrogenase classification

This classification of dehydrogenases and oxidoreductases is based mainly on the primary sequences. This classification is reasonably up-to-date, but from our point of view, some categories are named incorrectly. This means that in future these families of dehydrogenases will be change slightly, but further studies are necessary to do this.

This classification also contains few proteins with not known function and they are classified into some families only by some relations between primary structures with other well known dehydrogenases. You should be very careful to deal with this part of classification.

All families are sorted in alphabetical order and short description is given.

Families of dehydrogenases

  • 2-oxoacid dehydrogenase family
  • 3-hydroxyacyl-CoA dehydrogenase family
  • 3-hydroxyisobutyrate dehydrogenase family
  • 6-phosphogluconate dehydrogenase family
  • acyl-CoA dehydrogenase family
  • ALADH family
  • AlaDH/PNT family
  • aldehyde dehydrogenase family
    • AstD subfamily
    • Gamma-aminobutyraldehyde dehydrogenase subfamily
    • RocA subfamily
  • alpha-ketoglutarate dehydrogenase family
  • anaerobic G-3-P dehydrogenase subunit B family
  • aspartate-semialdehyde dehydrogenase family
  • bacterial PQQ dehydrogenase family
  • D-isomer specific 2-hydroxyacid dehydrogenase family
    • FDH subfamily
  • dadA oxidoreductase family
  • dihydroorotate dehydrogenase family
    • Type 1 subfamily
    • Type 2 subfamily
  • FAD-binding oxidoreductase/transferase type 4 family
  • FAD-dependent glycerol-3-phosphate dehydrogenase family
  • FAD-dependent oxidoreductase 2 family
    • FRD/SDH subfamily
    • NadB subfamily
  • FAD-dependent oxidoreductase family
  • FMN-dependent alpha-hydroxy acid dehydrogenase family
  • formate dehydrogenase gamma subunit family
  • Glu/Leu/Phe/Val dehydrogenases family
  • glucose-6-phosphate dehydrogenase family
  • glyceraldehyde-3-phosphate dehydrogenase family
  • glycerol-1-phosphate dehydrogenase family
  • GMC oxidoreductase family
  • histidinol dehydrogenase family
  • homoserine dehydrogenase family
  • IMPDH/GMPR family
    • GuaC type 1 subfamily
    • GuaC type 2 subfamily
  • iron-containing alcohol dehydrogenase family
  • isocitrate and isopropylmalate dehydrogenases family
    • LeuB type 1 subfamily
    • LeuB type 2 subfamily
  • L-aspartate dehydrogenase family
  • LDH/MDH superfamily
    • LDH family
    • MDH type 1 family
    • MDH type 2 family
    • MDH type 3 family
  • LDH2/MDH2 oxidoreductase family
    • DlgD subfamily
  • lysopine/nopaline/octopine/opine/vitopine dehydrogenases family
  • MADH light subunit family
  • mannitol dehydrogenase family
    • UxaB subfamily
    • UxuB subfamily
  • methanol dehydrogenase subunit 2 family
  • monomeric-type IDH family
  • NAD(P)H dehydrogenase (quinone) family
    • KefF subfamily
    • KefG subfamily
  • NAD-dependent glycerol-3-phosphate dehydrogenase family
  • NADH dehydrogenase family
  • NADH:flavin oxidoreductase/NADH oxidase family
    • NamA subfamily
  • NADP-dependent oxidoreductase L4BD family
  • NAGSA dehydrogenase family
    • Type 1 subfamily
    • Type 2 subfamily
  • Ni-containing carbon monoxide dehydrogenase family
  • oxygen-dependent FAD-linked oxidoreductase family
  • proline dehydrogenase family
  • pyridine nucleotide-disulfide oxidoreductase family class-I
  • pyridine nucleotide-disulfide oxidoreductase family class-II
  • pyridine nucleotide-disulfide oxidoreductase family class-III
  • saccharopine dehydrogenase family
  • shikimate dehydrogenase family
  • short-chain dehydrogenases/reductases (SDR) family
    • 17-beta-HSD 3 subfamily
    • 2,4-dienoyl-CoA reductase subfamily
    • ERG27 subfamily
    • FabI subfamily
    • POR subfamily
  • succinate dehydrogenase/fumarate reductase iron-sulfur protein family
  • tetrahydrofolate dehydrogenase/cyclohydrolase family
  • UDP-glucose/GDP-mannose dehydrogenase family
  • xanthine dehydrogenase family
  • zinc-containing alcohol dehydrogenase family
    • Class-I subfamily
    • Class-II subfamily
    • Class-III subfamily
    • Class-IV subfamily
    • Class-V subfamily
    • DOIA dehydrogenase subfamily
    • Quinone oxidoreductase subfamily

Not known and not classified dehydrogenases

  • FAD-binding oxidoreductase type 6 family
  • flavin oxidoreductase frp family
  • fre/luxG FAD/NAD(P) flavoprotein oxidoreductase family.
  • NmrA-type oxidoreductase family.
  • oxidoreductase yhhX family
  • PQQ oxidoreductase gdhB family

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